Cell, Gene and Therapy Journal

Peer-reviewed multi-disciplinary and Open Access journal accepts scientifically rigorous research, regardless of novelty

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The Functioning of Stem Cell and Transposable Elements in Nucleic Acid and Protein Mechanism

Shaabanpour Aghamaleki Fatemeh1, Sheikhpour Mojgan2, Kianpour Rad Sima3, Ekramnia Iman4, Keramatinia Aliasghar5, Mehrvar Narjes5, Safavi Naini Niloufar4, Movafagh Abolfazl*4
1. Department of Cellular-Molecular Biology, Faculty of Biological Sciences and Technologies, Shahid Beheshti University. Tehran, Iran
2. Department of Mycobacteriology and Pulmonary Research Microbiology, Research Center Pasteur Institute of Iran.
3. Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
4. Department of Medical Genetics, Cancer Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Transposable elements are mobile genetic units that exhibit broad diversity in their structure and transposition mechanisms. Transposable elements occupy a large fraction of many eukaryotic nucleic acid, protein and their movement and accumulation represent a major force shaping the genes and genomes of almost all organisms. Sequence repeats are an important phenomenon in the human genome, playing important roles in genomic alteration often with phenotypic consequences. The two major types of repeat elements in the human genome are tandem repeats (TRs) including microsatellites, minisatellites, and satellites and transposable elements (TEs).

Conclusion: TEs are contributing to genome expansion and alteration not only by transposition but also by generating tandem repeats. Finally, this article highlight how the distinctive biological features of DNA transposons have contributed to shape genome architecture and led to the emergence of genetic innovations in different eukaryotic nucleic acid, protein lineages.

Keywords : Transposable elements, satellite DNA, Nucleic acid, Protein, Organism

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