Cell, Gene and Therapy Journal

Peer-reviewed multi-disciplinary and Open Access journal accepts scientifically rigorous research, regardless of novelty

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Remarkable effects of Neptune krill oil and fish oil in combating inflammation and pain in mouse model by effect on TNFα and IL-6

Mojtahed Zadeh-Ardabili Parastoo*1
1Physiology department, Faculty of Medicine, University of Medical Science, Mashhad, Iran

Background: Although inflammation is a reactive to injurious stimuli and considered to be beneficial process in body, but it causes some discomforts, such as pain. Murine dietary which contain appreciable fatty-acids, antioxidants, encourage researchers to focus on their potential therapeutic effects. This study is aimed to examine the analgesic and anti-inflammatory activity of Neptune krill oil (NKO) and fish oil (FO) which are two well-known sources of rich content of n-3 polyunsaturated fatty acids (n-3 PUFAs), mostly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in rodent models. NKO and FO were used at same dose of 500 mg and also balanced at similar doses of EPA: 12 in NKO vs. 12 in FO wt%, DHA: 7 NKO vs. 8 FO wt%. Application of NKO and FO in acetic acid-induced writhing effect, hot plate, and formalin induced test, indicated the nociceptive activity of the two tested drugs in comparison with normal saline. Also, the anti-inflammatory effect of these supplements was confirmed by carrageenan test. Analysis of cytokines levels in the blood samples of the mice after induction inflammation by carrageenan indicated decreased levels of those proteins compared to that in the normal groups. Both tested drugs, effectively could reduce severe inflammation and pain in rodents in comparison with the references drugs (depends on the tests), however, NKO is almost found to be more potent than FO in the most assays.

Keywords : anti-nociceptive, anti-inflammation, Neptune krill oil, fish oil, n-3 PUFAs, EPA, DHA. IL-6, TNF-.


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