Cell, Gene and Therapy Journal

Peer-reviewed multi-disciplinary and Open Access journal accepts scientifically rigorous research, regardless of novelty

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Comparison of life quality in pre and posttreatment groups of patients with allergic rhinitis

Mafibordbar Sahar*1, Faghih Hossein1, Fathi Mohammad2
1 Gazvin University of Medical Science, Qazvin, Iran
2 Allergic and clinical Immunologist, Children Growth Research Center, Gazvin University of Medical Sciences, Qazvin, Iran

Introduction: Allergic rhinitis is a common problem in global health so that a quarter of the world population suffers from this disease. Also, the disease has a negative effect on the physical/psychological/ social performance of affected people and greatly affects the quality of life of patients. As a result, studies on the impact of current therapies on improving quality of life are important. Therefore, in this study, we examine the effect of treatment with a nasal spray of fluticasone and montelukast in the quality of life of patients.
Methods: 195 patients with allergic rhinitis aged 15-60 years from both sexes who candidates for treatment with nasal fluticasone (50 µg once daily) and montelukast (10mg per night) were randomly selected to examine the quality of life and the relative factors. The patient’s quality of life was measured prior and two weeks after the treatment, using Juniper internationally validated the questionnaire.
Results: In the current epidemiological study, women (59.5%) had a higher proportion of people with allergic rhinitis. Additionally, the highest prevalence of allergic rhinitis was seen among housewives (29.7%). The frequency of mild continuous allergic rhinitis (22.6%), intermittent (17.9%), and severe continuous type (15.9%) and intermittent (43.6%) was calculated. The results of this study showed that quality of life in 66.2% of patients was known to have made before any treatment intervention, and 33.8% had moderate-quality life defects. Two weeks after the start of treatment with fluticasone and montelukast, 172 (88.2%) had a mild quality of life defect and 23 (11.8%) had moderate to severe impairment in quality of life. Among the symptoms of nasal congestion, itching, and runny nose, frequent sneezing and pruritus, and runny nose, there was only a significant relationship between itching and runny nose and impaired quality of life after treatment. However, there was no association among the severity of the disease before treatment, age, sex, occupation, or asthma and quality of life after treatment (P> 0.05). In addition, there was a significant difference between sleep disorder before and after treatment with fluticasone and montelukast (P <0.001)
Conclusion: The results of this study showed that two-weeks combination therapy with fluticasone and oral montelukast, significantly improved the quality of life and sleep disturbance. Additionally, there was a significant relationship between pruritus and runny nose and impaired quality of life after treatment. This could be due to the improvement of these symptoms after receiving the treatments.

Keywords : allergic rhinitis, fluticasone, montelukast, quality of life


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